炎黄化工网-化工平台-中国化工网-天丰素-78821-43-9-C28H48O6

英文名: Epibrassinolide

CAS: 78821-43-9 分子式: C28H48O6

分子量: 480.677

别名:

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描述

Epibrassinolide(EBR)isabiologicallyactivecompoundofthebrassinosteroids,steroid-derivedplantgrowthregulatorfamily.Cellsareincubatedwithvariousdoses(0-100μM)ofEpibrassinolidefor24or48handcellviabilityisdeterminedbyMTTassay.Epibrassinolideinducedcellviabilitylossindose-andtime-dependentmannercomparedtountreatedsamplesinLNCaPandDU145prostatecancercells.IncreasingconcentrationsofEpibrassinolideismoreeffectiveonLNCaPcChemicalbookellviabilitylossthanDU145cellssuggestingthatandrogen-dependentcellsaremoresensitivetoEpibrassinolidethanandrogen-independentprostatecancercells.Infurtherexperiments,25μMEpibrassinolideisselectedduetoitsmoderatecytotoxiceffectonbothcelllines.TheeffectofEpibrassinolidetreatmentisexaminedoncellproliferationbycountingthecellnumberwithin96h.AhigherandearlierinhibitionofcellproliferationisobservedinLNCaPthanDU145cells.

基本信息

英文名:

Epibrassinolide

CAS号.:

78821-43-9

别名:

Brassinolide; 24-Epibrassinolide; (3aS,5S,6R,7aR,7bS,9aS,10R,12aS,12bS)-10-[(2S,3R,4R,5S)-3,4-dihydroxy-5,6-dimethylheptan-2-yl]-5,6-dihydroxy-7a,9a-dimethylhexadecahydro-3H-benzo[c]indeno[5,4-e]oxepin-3-one; (3aS,5S,6R,7aR,7bS,9aS,10R,12aS,12bS)-10-[(2S,3R,4R,5R)-3,4-dihydroxy-5,6-dimethylheptan-2-yl]-5,6-dihydroxy-7a,9a-dimethylhexadecahydro-3H-benzo[c]indeno[5,4-e]oxepin-3-one; (3aS,5S,6R,7aR,7bS,9aS,12aS,12bS)-10-[(1S,2S,3R,4R)-2,3-dihydroxy-1,4,5-trimethylhexyl]-5,6-dihydroxy-7a,9a-dimethylhexadecahydro-3H-benzo[c]indeno[5,4-e]oxepin-3-one;

分子式:

C28H48O6

分子量:

480.677

PSA:

LogP:

物化属性

外观:

White to Off-White

密度:

1.141g/cm³

熔点: