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巴氯芬

英文名: baclofen

CAS: 1134-47-0      分子式: C10H12ClNO2

分子量: 213.66100

别名:


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描述

Baclofen, sold under the brand name Lioresal, among others is a central nervous system depressant used as a skeletal muscle relaxant. It is primarily used to treat spasticity. It is also used as a muscle relaxant by compounding pharmacies in topical pain creams. It is a GABA receptor agonist, specifically of the GABAB receptors. Its beneficial effects in spasticity result from actions at spinal and supraspinal sites. It is a derivative of γ-aminobutyric acid (GABA). A beneficial property of baclofen is that tolerance to its muscle-related therapeutic benefits does not seem to occur to a significant degree — baclofen retains its therapeutic anti-spasmodic effects even after many years of continued use. Newer studies, however, indicate that tolerance may develop in some people receiving intrathecal baclofen treatment. As of 2015 the cost for a typical course of treatment in the United States is less than 25 USD.

基本信息
英文名:
baclofen
CAS号.:
1134-47-0
别名:
Baclofen; 4-Amino-3-(4-chlorophenyl)butyric Acid; LIORESAL; Atrofen; Clofen; baclon; 4-amino-3-(4-chlorophenyl)butanoic acid; Lioresa;
分子式:
C10H12ClNO2
分子量:
213.66100
PSA:
63.32000
LogP:
2.55730
物化属性
外观:
White to very light yellow solid
密度:
1.285 g/cm3
熔点:
208-210°C
沸点:
364.3ºC at 760 mmHg
闪点:
174.1ºC
储存条件:
Ventilated low temperature dry, separate storage with storehouse food material
安全信息
符号:
GHS06、GHS08
信号词:
Dangerous
危害声明:
H301; H315; H317; H319; H334; H335; H360
警示性声明:
P201; P261; P280; P301 + P310; P305 + P351 + P338; P308 + P313
海关编码:
2922499990
WGK Germany:
3
危险类别码:
R61; R25; R36/37/38; R42/43
安全说明:
53-22-36/37/39-45-52-36-26
危险品标志:
T
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