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艾地苯醌

英文名: idebenone

CAS: 58186-27-9      分子式: C19H30O5

分子量: 338.43900

别名:


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描述

Idebenone (trade names Catena, Raxone, Sovrima, among others) is a drug that was initially developed by Takeda Pharmaceutical Company for the treatment of Alzheimer's disease and other cognitive defects. This has been met with limited success. The Swiss company Santhera Pharmaceuticals has started to investigate it for the treatment of neuromuscular diseases. In 2010, early clinical trials for the treatment of Friedreich's ataxia and Duchenne muscular dystrophy have been completed. As of December 2013[update] the drug is not approved for these indications in North America or Europe, but it is approved for the treatment of Leber's hereditary optic neuropathy (LHON) in Europe. Chemically, idebenone is an organic compound of the quinone family. It is also promoted commercially as a synthetic analog of coenzyme Q10 (CoQ10).

基本信息
英文名:
idebenone
CAS号.:
58186-27-9
别名:
Idebenone; Idebenona [Spanish]; CV 2619; 2-(10-hydroxydecyl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione; UNII-HB6PN45W4J;
分子式:
C19H30O5
分子量:
338.43900
PSA:
72.83000
LogP:
3.46230
物化属性
外观:
From the oil ether to the orange needle-like crystallization, melting point 46~50℃. From hexane-acetic acid ethyl ester crystallization, melting point 52~53℃. Easily soluble in chloroform, methanol or anhydrous ethanol, soluble in acetic acid ethyl ester, soluble in most organic solvents, insoluble in N-hexane, a few insoluble in water.
密度:
1.08 g/cm3
熔点:
52-550C
沸点:
497.3ºC at 760 mmHg
闪点:
170.1ºC
储存条件:
Room temp
安全信息
危险品标志:
Xi
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