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苯妥英

英文名: phenytoin

CAS: 57-41-0      分子式: C15H12N2O2

分子量: 252.26800

别名:


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描述

Phenytoin, sold under the brand name Dilantin among others, is an anti-seizure medication. It is useful for the prevention of tonic-clonic seizures, partial seizures, but not absence seizures. The intravenous form is used for status epilepticus that does not improve with benzodiazepines. It may also be used for certain heart arrhythmias or neuropathic pain. It can be taken intravenously or by mouth. The intravenous form generally begins working within 30 minutes and is effective for 24 hours. Blood levels can be measured to determine the proper dose. Common side effects include nausea, stomach pain, loss of appetite, poor coordination, increased hair growth, and enlargement of the gums. Potentially serious side effects include sleepiness, self harm, liver problems, bone marrow suppression, low blood pressure, and toxic epidermal necrolysis. There is evidence that use during pregnancy results in abnormalities in the baby. It appears to be safe to use when breastfeeding. Alcohol may interfere with the medication's effects. Phenytoin was first made in 1908 by the German chemist Heinrich Biltz and found useful for seizures in 1936. It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system. Phenytoin is available as a generic medication and usually not too expensive. The wholesale cost in the developing world is between US$0.003 and US$0.15 per dose. A month of treatment is about US$30 in the United States.

基本信息
英文名:
phenytoin
CAS号.:
57-41-0
别名:
diphenyl hydantoin; Ekko; Epamin; Dilantin Kapseals; Denyl; Epised; Convul; 5,5-diphenyl-hydantoin; Eptal; Di-Lan; Hidan; Danten; 5,5-Diphenylhydantoin; 2,4-Imidazolidinedione, 5,5-diphenyl-; Phenytoin;
分子式:
C15H12N2O2
分子量:
252.26800
PSA:
58.20000
LogP:
2.42720
物化属性
外观:
White crystals or powders
密度:
1.257g/cm3
熔点:
293-295 °C(lit.)
沸点:
闪点:
11 °C
储存条件:
2-8ºC
安全信息
符号:
GHS07、GHS08
信号词:
Dangerous
危害声明:
H302; H350; H360
警示性声明:
P201; P280; P301 + P312 + P330; P308 + P313
海关编码:
29332100
WGK Germany:
3
危险类别码:
R22; R40; R45; R61; R63
安全说明:
S53-S45-S36/37-S16-S7
危险品标志:
T
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