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英文名: mupirocin

CAS: 12650-69-0      分子式: C26H44O9

分子量: 500.62200

别名:


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描述

Mupirocin (trade names Bactroban, Centany) is an antibiotic. It is used topically and is effective against Gram-positive bacteria, including MRSA. Mupirocin is inactive for most anaerobic bacteria, mycobacteria, mycoplasma, chlamydia, yeast and fungi. Mupirocin is bacteriostatic at low concentrations and bactericidal at high concentrations. It is of the monoxycarbolic acid class. Mupirocin is a mixture of several pseudomonic acids, with pseudomonic acid A (PA-A) constituting greater than 90% of the mixture. Also present in mupirocin are pseudomonic acid B with an additional hydroxyl group at C8, pseudomonic acid C with a double bond between C10 and C11, instead of the epoxide of PA-A, and pseudomonic acid D with a double bond at C4` and C5` in the 9-hydroxy-nonanoic acid portion of mupirocin. It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system. It was originally isolated from Pseudomonas fluorescens, developed by Beecham.

基本信息
英文名:
mupirocin
CAS号.:
12650-69-0
别名:
Bactroban; Mupirocinum; Bactroban Nasal; Pseudomonic acid; 9-[(E)-4-[(2S,3R,4R,5S)-3,4-dihydroxy-5-[[(2S,3S)-3-[(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl]methyl]oxan-2-yl]-3-methylbut-2-enoyl]oxynonanoic acid; Mupirocine; Plasimine; Mupirocina; Mupirocin; Pseudomonic acid A; Centany;
分子式:
C26H44O9
分子量:
500.62200
PSA:
146.05000
LogP:
2.59250
物化属性
外观:
Solid
密度:
1.183 g/cm3
熔点:
77-780C
沸点:
672.3ºC at 760 mmHg
闪点:
216.5ºC
储存条件:
Store cool, dark and dry.
安全信息
海关编码:
2941909000
WGK Germany:
2
安全说明:
S2
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