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丁酸钠

英文名: sodium butyrate

CAS: 156-54-7      分子式: C4H7NaO2

分子量: 110.08700

别名:


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描述

Sodium butyrate is a compound with formula Na(C3H7COO). It is the sodium salt of butyric acid. It has various effects on cultured mammalian cells including inhibition of proliferation, induction of differentiation and induction or repression of gene expression. As such, it can be used in lab to bring about any of these effects. Specifically, butyrate treatment of cells results in histone hyperacetylation, and butyrate itself inhibits class I histone deacetylase (HDAC) activity, specifically HDAC1, HDAC2, HDAC3, and HDAC8. Butyrate has been an essential vehicle for determining the role of histone acetylation in chromatin structure and function. Inhibition of HDAC activity is estimated to affect the expression of only 2% of mammalian genes. In the lab, sodium butyrate is usually found as a white, water-soluble, crystalline solid. The chemical is notable for having a very strong, unpleasant smell that lingers. When working with sodium butyrate, gloves, eye protection and respiratory masks are advised for safety purposes. The compound is found in human diet, notably produced in large amounts from dietary fiber in the gut and present in Parmesan cheese and butter.

基本信息
英文名:
sodium butyrate
CAS号.:
156-54-7
别名:
Natriumbutyrat; Butyrate sodium salt; NAB; BUTYRIC ACID NA; SODIUMBUTYRATE,USP;
分子式:
C4H7NaO2
分子量:
110.08700
PSA:
40.13000
LogP:
物化属性
外观:
White powder
密度:
0.987g/cm3
熔点:
250-253 °C(lit.)
沸点:
164.3ºC at 760 mmHg
闪点:
69.7ºC
储存条件:
The storehouse is low temperature, ventilated, dry
安全信息
符号:
GHS07
信号词:
Warning
危害声明:
H315; H319; H335
警示性声明:
P305 + P351 + P338
海关编码:
2915600000
WGK Germany:
1
危险类别码:
R36/37/38
安全说明:
S37/39-S26-S24/25
危险品标志:
Xi
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