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醋酸氟轻松

英文名: fluocinolone acetonide

CAS: 67-73-2      分子式: C24H30F2O6

分子量: 452.48800

别名:


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描述

Fluocinolone acetonide is a corticosteroid primarily used in dermatology to reduce skin inflammation and relieve itching. It is a synthetic hydrocortisone derivative. The fluorine substitution at position 9 in the steroid nucleus greatly enhances its activity. It was first synthesized in 1959 in the Research Department of Syntex Laboratories S.A. Mexico City. Preparations containing it were first marketed under the name Synalar. A typical dosage strength used in dermatology is 0.01–0.025%. One such cream is sold under the brand name Flucort-N and includes the antibiotic neomycin. Fluocinolone acetonide was also found to strongly potentiate TGF-β-associated chondrogenesis of bone marrow mesenchymal stem/progenitor cells, by increasing the levels of collagen type II by more than 100 fold compared to the widely used dexamethasone. Fluocinolone acetonide intravitreal implants have been used to treat non-infectious uveitis. A systematic review could not determine whether fluocinolone acetonide implants are superior to standard of care treatment for uveitis. Flucinolone is a group V (0.025%) or group VI (0.01%) corticosteroid under US classification.

基本信息
英文名:
fluocinolone acetonide
CAS号.:
67-73-2
别名:
分子式:
C24H30F2O6
分子量:
452.48800
PSA:
93.06000
LogP:
2.36680
物化属性
外观:
密度:
1.36g/cm3
熔点:
267-269 °C(lit.)
沸点:
579ºC
闪点:
储存条件:
Keep tightly closed. Store in a cool dry place.
安全信息
海关编码:
2937210000
WGK Germany:
3
危险类别码:
R20/21/22; R36/37/38; R40
安全说明:
S26-S36-S22
危险品标志:
Xn
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