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英文名: amlodipine

CAS: 88150-42-9      分子式: C20H25ClN2O5

分子量: 408.87600

别名:


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描述

Amlodipine, sold under the brand name Norvasc among others, is a medication used to treat high blood pressure and coronary artery disease. While calcium channel blockers are not typically recommended in heart failure, amlodipine may be used if other medications are not sufficient for high blood pressure or heart related chest pain. Amlodipine is taken by mouth and has an effect for at least a day. Common side effects include: swelling, feeling tired, abdominal pain, and nausea. Serious side effects may include low blood pressure or a heart attack. It is unclear if use is safe during pregnancy or breastfeeding. Doses should be decreased in people with liver problems and those who are old. Amlodipine is a long acting calcium channel blocker of the dihydropyridine type. It works partly by increasing the size of arteries. Amlodipine was first patented in 1986 with commercial sale beginning in 1990. It is on the WHO Model List of Essential Medicines, the most important medications needed in a basic health system. It is available as a generic medication. Wholesale cost in the developing world is 0.003 to 0.040 USD per day for a typical dose as of 2014. In the United States a months supply costs less than 25 USD.

基本信息
英文名:
amlodipine
CAS号.:
88150-42-9
别名:
Norvasc; Amlodipino; 3-ethyl 5-methyl ()-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridine dicarboxylate; Amlodipinum; 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester; 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine; 3-ethyl-5-methyl-(4RS)-2-[(2-aminoethoxy)-methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-carboxylate benzene sulphonate; Lipinox; Istin; (R,S)-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine; Amlocard; Amlodis; Coroval; Amlodipinum [Latin];
分子式:
C20H25ClN2O5
分子量:
408.87600
PSA:
99.88000
LogP:
3.29540
物化属性
外观:
Yellow Solid
密度:
1.227 g/cm3
熔点:
178-179ºC
沸点:
527.2ºC at 760 mmHg
闪点:
储存条件:
-20ºC Freezer
安全信息
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2942000000
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