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氯哌斯汀

英文名: 1-[2-[(4-chlorophenyl)-phenylmethoxy]ethyl]piperidine

CAS: 3703-76-2      分子式: C20H24ClNO

分子量: 329.86400

别名:


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描述

Cloperastine (INN) or cloperastin, also known as cloperastine hydrochloride (JAN) (brand names Hustazol, Nitossil, Seki) and cloperastine fendizoate (or hybenzoate), is an antitussive and antihistamine that is marketed as a cough suppressant in Japan, Hong Kong, and in some European countries. It was first introduced in 1972 in Japan, and then in Italy in 1981. The precise mechanism of action of cloperastine is not fully clear, but several different biological activities have been identified for the drug, of which include: ligand of the σ1 receptor (Ki = 20 nM) (likely an agonist), GIRK channel blocker (described as "potent"), antihistamine (Ki = 3.8 nM for the H1 receptor), and anticholinergic. It is thought that the latter two properties contribute to side effects, such as sedation and somnolence, while the former two may be involved in or responsible for the antitussive efficacy of cloperastine.

基本信息
英文名:
1-[2-[(4-chlorophenyl)-phenylmethoxy]ethyl]piperidine
CAS号.:
3703-76-2
别名:
Cloperastine; EINECS 223-042-3;
分子式:
C20H24ClNO
分子量:
329.86400
PSA:
12.47000
LogP:
4.86980
物化属性
外观:
密度:
1.12g/cm3
熔点:
沸点:
423.9ºC at 760mmHg
闪点:
210.2ºC
储存条件:
安全信息
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