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恩他卡朋

英文名: entacapone

CAS: 130929-57-6      分子式: C14H15N3O5

分子量: 305.28600

别名:


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描述

Entacapone (INN) is a medication commonly used in combination with other medications for the treatment of Parkinson's disease. Entacapone together with levodopa and carbidopa allows levodopa to have a longer effect in the brain and reduces Parkinson’s disease signs and symptoms for a greater length of time than levodopa and carbidopa therapy alone. Entacapone is known as a selective and reversible inhibitor of the enzyme catechol-O-methyltransferase (COMT). When taken together with levodopa (L-DOPA) and carbidopa, entacapone stops catechol-O-methyltransferase from breaking down and metabolizing levodopa, resulting in an overall increase of levodopa remaining in the brain and body. Entacapone is developed by Orion Pharma and marketed by Novartis under the trade name Comtan. Stalevo, another medication developed by Orion Pharma and marketed by Novartis, is a single tablet formulation that contains levodopa, carbidopa, and entacapone.

基本信息
英文名:
entacapone
CAS号.:
130929-57-6
别名:
OR-611; Comtes; 2-Cyano-N,N-diethyl-3-(3,4-dihydroxy-5-nitrophenyl)propenamide; Comtess; Entacapone; Comtan;
分子式:
C14H15N3O5
分子量:
305.28600
PSA:
130.38000
LogP:
2.30458
物化属性
外观:
Yellow Powder
密度:
1.392g/cm3
熔点:
162-1630C
沸点:
526.6ºC at 760 mmHg
闪点:
272.3ºC
储存条件:
安全信息
海关编码:
2942000000
WGK Germany:
1
危险类别码:
R10; R20/21/22; R37/38; R41; R62; R38; R36/37/38
安全说明:
S26; S36; S39; S45
危险品标志:
Xn; T; F
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