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英文名: zileuton

CAS: 111406-87-2      分子式: C11H12N2O2S

分子量: 236.29000

别名:


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描述

Zileuton (trade name ZYFLO) is an orally active inhibitor of 5-lipoxygenase, and thus inhibits leukotrienes (LTB4, LTC4, LTD4, and LTE4) formation. Zileuton is used for the maintenance treatment of asthma. Zileuton was introduced in 1996 by Abbott Laboratories and is now marketed in two formulations by Cornerstone Therapeutics Inc. under the brand names ZYFLO and ZYFLO CR. The original immediate-release formulation of zileuton, known as ZYFLO, is taken four times per day. The extended-release formulation, ZYFLO CR, is taken twice daily. Although the 600mg immediate release tablet (Zyflo) and extended release formulation of zileuton is still available (Zyflo CR), the 300mg immediate release tablet was withdrawn from the U.S. market on February 12, 2008.

基本信息
英文名:
zileuton
CAS号.:
111406-87-2
别名:
Zileuton; Leutrol; N-hydroxy-N-{1-(benzo[b]thien-2-yl)ethyl}urea; 1-(1-(Benzo[b]thiophen-2-yl)ethyl)-1-hydroxyurea; 1-(1-benzo[b]thien-2-ylethyl)-1-hydroxyurea; Leutml; ZYFLO; Zyfl;
分子式:
C11H12N2O2S
分子量:
236.29000
PSA:
94.80000
LogP:
3.43250
物化属性
外观:
Crystalline solids
密度:
1.401 g/cm3
熔点:
157-158°C
沸点:
449.4ºC at 760 mmHg
闪点:
225.6ºC
储存条件:
Store in original container in a cool dark place
安全信息
符号:
GHS07
信号词:
Warning
危害声明:
H302; H319
警示性声明:
P305 + P351 + P338
海关编码:
2934999090
WGK Germany:
3
危险品标志:
Xi
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