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耐法唑酮

英文名: nefazodone

CAS: 83366-66-9      分子式: C25H32ClN5O2

分子量: 470.00700

别名:


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描述

Nefazodone (Dutonin, Nefadar, Serzone) is an antidepressant marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries due to the rare incidence of hepatotoxicity (liver damage), which could lead to the need for a liver transplant, or even death. The incidence of severe liver damage is approximately 1 in every 250,000 to 300,000 patient-years. On June 14, 2004, Bristol-Myers Squibb discontinued the sale of Serzone in the United States and Canada. Several generic formulations of nefazodone are still available.

基本信息
英文名:
nefazodone
CAS号.:
83366-66-9
别名:
2-<3-<4-(3-chlorophenyl)-1-piperazinyl>propyl>-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazolin-3-one; Nefazodonum [Latin]; Nefazodonum; 2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-4-(2-phenoxyethyl)-2H-1,2,4-triazol-3(4H)-one; 2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-5-ethyl-4-(2-phenoxyethyl)-1,2,4-triazol-3-one; Nefazodone (INN); UNII-59H4FCV1TF; Nefazodona [Spanish]; Nefazodone Hcl; 2-[3-[4-(3-chlorophenyl)-1-piperazinyl]-propyl-]5-ethyl-2,4-dihydro-4-(2-phenoxy-ethyl)-3H-1,2,4-triazol-3-one; [14C]-Nefazodone hydrochloride; Nefazodona;
分子式:
C25H32ClN5O2
分子量:
470.00700
PSA:
55.53000
LogP:
3.55480
物化属性
外观:
White to off-white crystalline powder
密度:
熔点:
180-182°C
沸点:
闪点:
储存条件:
安全信息
WGK Germany:
3
安全说明:
S22-S24/25
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