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哌非尼酮

英文名: pirfenidone

CAS: 53179-13-8      分子式: C12H11NO

分子量: 185.22200

别名:


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描述

Pirfenidone (INN, BAN) is an anti-fibrotic drug for the treatment of idiopathic pulmonary fibrosis (IPF). It works by reducing lung fibrosis through downregulation of the production of growth factors and procollagens I and II. It is a drug developed by several companies worldwide, including InterMune Inc. (now part of Roche), Shionogi Ltd., and GNI Group Ltd. In 2008, it was first approved in Japan for the treatment of IPF after clinical trials, under the trade name of Pirespa by Shionogi & Co. In October 2010, the Indian Company Cipla launched it as Pirfenex. In 2011, it was approved for use in Europe for IPF under the trade name Esbriet; it was approved in Canada in 2012 under the trade name Esbriet; and was approved in the United States in October 2014 under the same name. In September 2011, the Chinese State Food and Drug Administration provided GNI Group Ltd with new drug approval of pirfenidone in China, and later manufacture approval in 2013 under the trade name of Etuary. In 2014 it was approved in Mexico under the name KitosCell LP, indicated for pulmonary fibrosis and liver fibrosis. There is also a topical form created for the treatment of abnormal wound healing processes.

基本信息
英文名:
pirfenidone
CAS号.:
53179-13-8
别名:
Pirfenidone; 5-Methyl-N-phenyl-2-1H-pyridone; 5-methyl-1-phenyl-1H-pyridin-2-one; 5-Methyl-1-phenyl-2-(1H)-pyridone; 5-methyl-1-phenyl-pyridin-2-one; amr-69; 5-Methyl-1-phenylpyridin-2(1H)-one; TORASEMIDETECHPIRFENIDONE; 5-methyl-1-phenyl-2-pyridone; 5-Methyl-1-phenyl-2-pyridone; S-7701;
分子式:
C12H11NO
分子量:
185.22200
PSA:
22.00000
LogP:
2.14590
物化属性
外观:
密度:
1.137 g/cm3
熔点:
96-97ºC
沸点:
329.1ºC at 760 mmHg
闪点:
152.7ºC
储存条件:
Store at RT
安全信息
符号:
GHS07
信号词:
Warning
危害声明:
H302
海关编码:
2933399090
WGK Germany:
3
危险类别码:
R22
安全说明:
S36
危险品标志:
Xn
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