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五氟利多

英文名: 1-[4,4-bis(4-fluorophenyl)butyl]-4-[4-chloro-3-(trifluoromethyl)phenyl]piperidin-4-ol

CAS: 26864-56-2      分子式: C28H27ClF5NO

分子量: 523.96500

别名:


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描述

Penfluridol (Semap, Micefal, Longoperidol) is a highly potent, first generation diphenylbutylpiperidine antipsychotic. It was discovered at Janssen Pharmaceutica in 1968. Related to other diphenylbutylpiperidine antipsychotics, pimozide and fluspirilene, penfluridol has an extremely long elimination half-life and its effects last for many days after single oral dose. Its antipsychotic potency, in terms of dose needed to produce comparable effects, is similar to both haloperidol and pimozide. It is only slightly sedative, but often causes extrapyramidal side-effects, such as akathisia, dyskinesiae and pseudo-Parkinsonism. Penfluridol is indicated for antipsychotic treatment of chronic schizophrenia and similar psychotic disorders, it is, however, like most typical antipsychotics, being increasingly replaced by the atypical antipsychotics. Due to its extremely long-lasting effects, it is often prescribed to be taken orally as tablets only once a week (q 7 days). The once-weekly dose is usually 10–60mg.

基本信息
英文名:
1-[4,4-bis(4-fluorophenyl)butyl]-4-[4-chloro-3-(trifluoromethyl)phenyl]piperidin-4-ol
CAS号.:
26864-56-2
别名:
McN-JR-16,341; TLP-607; 1-[4,4-Bis(4-fluorophenyl)butyl]-4-[4-chloro-3(trifluoromethyl)phenyl]-4-piperidinol,R16341; EINECS 248-074-5; 1-(4,4-Bis(4-fluorophenyl)butyl)-4-(4-chloro-3-(trifluoromethyl)phenyl)piperidin-4-ol; 1-[4,4-Bis(4-fluorophenyl)butyl]-4-[4-chloro-3-(trifluoromethyl)phenyl]-4-piperidinol; Semap; [3H]-Penfluridol; 1-[4,4-Bis(4-fluorophenyl)butyl]-4-[4-chloro-3(trifluoromethyl)phenyl]-4-piperidinol R16341; Penfluridol; PENFLURIDOL;
分子式:
C28H27ClF5NO
分子量:
523.96500
PSA:
23.47000
LogP:
7.47060
物化属性
外观:
Off-white to white crystalline powder
密度:
1.29 g/cm3
熔点:
105-107ºC
沸点:
587.7ºC at 760 mmHg
闪点:
309.2ºC
储存条件:
2-8ºC
安全信息
符号:
GHS06
信号词:
Dangerous
危害声明:
H301
警示性声明:
P301 + P310
海关编码:
2942000000
WGK Germany:
3
危险类别码:
R25
安全说明:
S45
危险品标志:
T
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