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乌拉地尔

英文名: 6-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino]-1,3-dimethylpyrimidine-2,4-dione

CAS: 34661-75-1      分子式: C20H29N5O3

分子量: 387.47600

别名:


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描述

Urapidil is a sympatholytic antihypertensive drug. It acts as an α1-adrenoceptor antagonist and as an 5-HT1A receptor agonist Although an initial report suggested that urapidil was also an α2-adrenoceptor agonist, this was not substantiated in later studies that demonstrated it was devoid of agonist actions in the dog saphenous vein and the guinea-pig ileum. Unlike some other α1-adrenoceptor antagonists, urapidil does not elicit reflex tachycardia, and this may be related to its weak β1-adrenoceptor antagonist activity, as well as its effect on cardiac vagal drive. Urapidil is currently not approved by the U.S. Food and Drug Administration, but it is available in Europe.

基本信息
英文名:
6-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino]-1,3-dimethylpyrimidine-2,4-dione
CAS号.:
34661-75-1
别名:
urapidil(jan); Urapidilum [INN-Latin]; 6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil; Ebrantil; 6-{3-[4-(2-methoxy-phenyl)-piperazin-1-yl]-propylamino}-1,3-dimethyl-1H-pyrimidine-2,4-dione;
分子式:
C20H29N5O3
分子量:
387.47600
PSA:
71.74000
LogP:
0.79270
物化属性
外观:
密度:
1.26 g/cm3
熔点:
沸点:
549ºC at 760 mmHg
闪点:
285.8ºC
储存条件:
安全信息
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