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三氯苯哒唑

英文名: Triclabendazole

CAS: 68786-66-3      分子式: C14H9Cl3N2OS

分子量: 359.65800

别名:


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描述

Triclabendazole (commercial names: veterinary, liquid: Fasinex; human, tablets: Egaten, both manufactured by Novartis) is a member of the benzimidazole family of anthelmintics. The benzimidazole drugs share a common molecular structure, triclabendazole being the exception in having a chlorinated benzene ring but no carbamate group. Benzimidazoles such as triclabendazole are generally accepted to bind to beta-tubulin and prevent the polymerization of the microtubules of which they are part. Triclabendazole was initially only developed as an oral route drug, and displays high efficacy against both immature and adult liver flukes. Since late 1990s, triclabendazole became available as a generic drug, as patents expired in many countries. Many products were developed then. Among them, Trivantel 15, a 15% triclabendazole suspension, was launched by Agrovet Market Animal Health in the early 2000s. In 2009, the first triclabendazole injectable solution (combined with ivermectin) was developed and launched, also by Agrovet Market Animal Health. The product, Fasiject Plus, a triclabendazole 36% and ivermectin 0.6% solution, is designed to treat infections by Fasciola hepatica (both immature and adult liver flukes), roundworms and ectoparasites, as well. It is on the World Health Organization's List of Essential Medicines, the most important medication needed in a basic health system.

基本信息
英文名:
Triclabendazole
CAS号.:
68786-66-3
别名:
6-Chloro-5-(2,3-dichlorophenoxy)-2-methylthio-benzimidazole
分子式:
C14H9Cl3N2OS
分子量:
359.65800
PSA:
63.21000
LogP:
6.03730
物化属性
外观:
White to brown crystalline powder
密度:
1.59 g/cm3
熔点:
175-176°C
沸点:
495.9ºCat 760 mmHg
闪点:
253.7ºC
储存条件:
The storehouse is low temperature, ventilated, dry
安全信息
海关编码:
2933990090
WGK Germany:
3
危险类别码:
R36/37/38
安全说明:
S26; S36
危险品标志:
Xn
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