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灰黄霉素

英文名: griseofulvin

CAS: 126-07-8      分子式: C17H17ClO6

分子量: 352.76600

别名:


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描述

Griseofulvin (trade names: Gris-peg and Grifulvin V) is an orally administered antifungal drug. It is used both in animals and humans, to treat fungal infections of the skin (commonly known as ringworm) and nail fungus. It was discovered in the culture broth of certain species of the mold Penicillium in 1939. It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system. It is produced industrially by fermenting the fungus Penicillium patulum.

基本信息
英文名:
griseofulvin
CAS号.:
126-07-8
别名:
Griseofulvin Permeability Diameter; (1’S,6’R)-7-chloro-2’,4,6-trimethoxy-6’-methylspiro[benzofuran-2(3H),1’-[2]cyclohexene]-3,4’-dione; Spiro[benzofuran-2(3H),1‘-[2]cyclohexene]-3,4‘-dione, 7-chloro-2‘,4,6-trimethoxy-6‘-methyl-, (1‘S-trans)-; (1’S-trans)- 7-chloro-2’,4,6-trimethoxy-6’-methylspiro[benzofuran-2(3H),1’-cyclohex-2’-ene]-3,4’-dione; (2S,5'R)-7-chloro-3',4,6-trimethoxy-5'-methylspiro[1-benzofuran-2,4'-cyclohex-2-ene]-1',3-dione; Griseofulvin; (+)-Griseofulvin; 7-chloro-4,6-dimethoxycoumaran-3-one-2-spiro-1’-(2’-methoxy-6’-methylcyclohex-2’-en-4’-one);
分子式:
C17H17ClO6
分子量:
352.76600
PSA:
71.06000
LogP:
2.81030
物化属性
外观:
White to pale creamy crystalline powder odorless or near odorless.
密度:
1.38g/cm3
熔点:
218-220 °C(lit.)
沸点:
570.4ºC at 760mmHg
闪点:
228ºC
储存条件:
Warehouse ventilation is low temperature dry, separate storage and transportation with food raw materials
安全信息
符号:
GHS07、GHS08
信号词:
Dangerous
危害声明:
H317; H351; H360
警示性声明:
P201; P280; P308 + P313
WGK Germany:
3
危险类别码:
R60; R61; R40; R43
安全说明:
S53-S22-S36/37/39-S45
危险品标志:
T
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