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他达那非

英文名: Tildenafil

CAS: 171596-29-5      分子式: C22H19N3O4

分子量: 389.40400

别名:


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描述

Tadalafil is a PDE5 inhibitor marketed in pill form for treating erectile dysfunction (ED) under the name Cialis, and under the name Adcirca for the treatment of pulmonary arterial hypertension. In October 2011 the U.S. Food and Drug Administration (FDA) approved Cialis for treating the signs and symptoms of benign prostatic hyperplasia (BPH) as well as a combination of BPH and erectile dysfunction (ED) when the conditions coincide. It initially was developed by the biotechnology company ICOS, and then again developed and marketed world-wide by Lilly ICOS, LLC, the joint venture of ICOS Corporation and Eli Lilly and Company. Cialis tablets, in 2.5mg, 5mg, 10mg, and 20mg doses, are yellow, film-coated, and almond-shaped. The approved dose for pulmonary arterial hypertension is 40mg (two 20-mg tablets) once daily. Tadalafil is also manufactured and sold under the name of Tadacip by the Indian pharmaceutical company Cipla in doses of 10mg and 20mg. On November 21, 2003 the FDA approved tadalafil (as Cialis) for sale in the United States as the third ED prescription drug pill (after sildenafil citrate (Viagra) and vardenafil Hydrochloride (Levitra)). Like sildenafil and vardenafil, tadalafil is recommended as an 'as needed' medication. Cialis is the only one of the three that is also offered as a once-daily medication. Moreover, tadalafil was approved in May 2009 in the United States for the treatment of pulmonary arterial hypertension and is under regulatory review in other regions for this condition. In late November 2008, Eli Lilly sold the exclusive rights to commercialize tadalafil for pulmonary arterial hypertension in the United States to United Therapeutics for an upfront payment of $150 million.

基本信息
英文名:
Tildenafil
CAS号.:
171596-29-5
别名:
Cialis; (6R,12aR)-6-(benzo[d][1,3]dioxol-5-yl)-2-methyl-2,3,12,12a tetrahydropyrazino [1',2':1,6] pyrido[3,4b] indole1,4(6H,7H)-dione; (6R,12aR)-6-(1,3-benzodioxol-5-yl)-2-methyl-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6] pyrido[3,4-b]indole-1,4-dione;
分子式:
C22H19N3O4
分子量:
389.40400
PSA:
74.87000
LogP:
2.08710
物化属性
外观:
Gray-White crystalline solid
密度:
1.51 g/cm3
熔点:
298-300ºC
沸点:
679.1ºC at 760 mmHg
闪点:
364.5ºC
储存条件:
安全信息
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