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氟胞嘧啶

英文名: flucytosine

CAS: 2022-85-7      分子式: C4H4FN3O

分子量: 129.09200

别名:


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描述

Flucytosine, or 5-fluorocytosine, a fluorinated pyrimidine analogue, is a synthetic antimycotic drug. It is structurally related to the cytostatic fluorouracil and to floxuridine. It is available in oral and in some countries also in injectable form. A common brand name is Ancobon. Flucytosine was first synthesized in 1957 but its antifungal properties were discovered in 1964. The drug is dispensed in capsules of 250mg and 500mg strength. The injectable form is diluted in 250mL saline solution to contain 2.5g total (10mg/mL). The solution is physically incompatible with other drugs including amphotericin B. It is on the World Health Organization's List of Essential Medicines, the most important medication needed in a basic health system.

基本信息
英文名:
flucytosine
CAS号.:
2022-85-7
别名:
4-amino-5-fluoro-1,2-dihydropyrimidin-2-one; 4-Amino-5-fluoro-2(1H)-pyrimidinone; 5-Fluorocytosine; Fluocytosine; 6-amino-5-fluoro-1H-pyrimidin-2-one; Flucytosin; Ancotil; 4-amino-5-fluoro-2(1H)-pyrimidinone,5-Fluorocytosine,Flucytosine; 5-Fluorocytosin; 4-amino-5-fluoro-2(1H)-pyrimidinone,Flucytosine; 4-Amino-5-fluoro-2-hydroxypyrimidine; Fluorcytosine; Flucytosine; Ancobon; 5-Fluorocystosine; 4-amino-5-fluoro-2-pyrimidone;
分子式:
C4H4FN3O
分子量:
129.09200
PSA:
71.77000
LogP:
0.07240
物化属性
外观:
White crystalline Solid
密度:
1.73g/cm3
熔点:
298-300 °C (dec.)(lit.)
沸点:
298ºC
闪点:
储存条件:
2-8ºC
安全信息
符号:
GHS08
信号词:
Warning
危害声明:
H361
警示性声明:
P281
海关编码:
2933599090
WGK Germany:
2
危险类别码:
R40
安全说明:
S22-S24/25-S45-S36/37
危险品标志:
Xn
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