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环孢菌素

英文名: cyclosporin A

CAS: 59865-13-3      分子式: C62H111N11O12

分子量: 1202.61000

别名:


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描述

Ciclosporin, also spelled cyclosporine, is an immunosuppressant drug widely used in organ transplantation to prevent rejection. It reduces the activity of the immune system by interfering with the activity and growth of T cells. It was initially isolated from the fungus Tolypocladium inflatum found in a soil samples in 1969 from Norway, by Hans Peter Frey. Most peptides are synthesized by ribosomes, but ciclosporin is a cyclic nonribosomal peptide of 11 amino acids and contains a single D-amino acid, which is rarely encountered in nature. It is on the WHO Model List of Essential Medicines, the most important medications needed in a basic health system.

基本信息
英文名:
cyclosporin A
CAS号.:
59865-13-3
别名:
s7481f1; Neoral; Atopica; sandimmun neoral; ciclosporin A; Restasis; Cipol N; cyclosporine A; sandimmun; ol27-400; Cyclosporin A; Neoplanta; Sandimmun optoral; Optimmune;
分子式:
C62H111N11O12
分子量:
1202.61000
PSA:
278.80000
LogP:
4.14950
物化属性
外观:
密度:
1.016 g/cm3
熔点:
148-151°C
沸点:
1293.8ºC at 760 mmHg
闪点:
736.3ºC
储存条件:
2-8°C
安全信息
海关编码:
2941909000
WGK Germany:
3
危险类别码:
R45; R60; R22
安全说明:
53-45-36/37-24/25-22
危险品标志:
T
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