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英文名: lansoprazole

CAS: 103577-45-3      分子式: C16H14F3N3O2S

分子量: 369.36100

别名:


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描述

Lansoprazole is a proton-pump inhibitor (PPI) which inhibits the stomach's production of gastric acids. It is manufactured by a number of companies worldwide under several brand names. In the United States, it was first approved by the Food and Drug Administration (FDA) in 1995. Prevacid patent protection expired on November 10, 2009. There is not evidence that its effectiveness is different than that of other PPIs. Lansoprazole is a proton-pump inhibitor (PPI) in the same pharmacologic class as omeprazole. Lansoprazole has been marketed for many years and is one of several PPIs available. It is a racemic 1:1 mixture of the enantiomers dexlansoprazole (Dexilant, formerly named Kapidex) and levolansoprazole. Dexlansoprazole is an enantiomerically pure active ingredient of a commercial drug as a result of the enantiomeric shift. Lansoprazole's plasma elimination half-life (1.5 h) is not proportional to the duration of the drug's effects to the person (i.e. gastric acid suppression). and the effects of the drug last for over 24 hours after it has been used for a day or more. Lansoprazole, given nasogastrically, effectively controls intragastric pH and is an alternative to intravenous pantoprazole in people who are unable to swallow solid-dose formulations.

基本信息
英文名:
lansoprazole
CAS号.:
103577-45-3
别名:
Lanz; OGAST; Lancid; LANZOR; Promp; Zoton; Ulpax; Ketian; Lansoprazole; 2-[[[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]benzimidazole; LANSOX;
分子式:
C16H14F3N3O2S
分子量:
369.36100
PSA:
87.08000
LogP:
4.38090
物化属性
外观:
White crystalline powder
密度:
1.5 g/cm3
熔点:
178-182°C dec.
沸点:
555.8ºC at 760 mmHg
闪点:
289.9ºC
储存条件:
2-8ºC
安全信息
海关编码:
2933990090
WGK Germany:
2
危险类别码:
R36/37/38
安全说明:
S26-S36
危险品标志:
Xi
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