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右佐匹克隆

英文名: eszopiclone

CAS: 138729-47-2      分子式: C17H17ClN6O3

分子量: 388.80800

别名:


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描述

Eszopiclone, marketed by Sunovion under the brand-name Lunesta, is a nonbenzodiazepine hypnotic which is slightly effective for insomnia. Eszopiclone is the active dextrorotatory stereoisomer of zopiclone, and belongs to the class of drugs known as cyclopyrrolones. Eszopiclone (Lunesta) along with other "Z-drugs" including zolpidem (Ambien), zaleplon (Sonata) are the most commonly prescribed sedative hypnotics in the United States. Eszopiclone is not marketed in the European Union following a 2009 decision by the EMA denying it new active substance status, in which it ruled that eszopiclone was too similar to zopiclone to be considered a new patentable product. Eszopiclone is now available in a generic form in the United States as of May 2014. On May 15, 2014, the USFDA asked that the starting dose of Eszopiclone (Lunesta) be lowered from 2 milligrams to 1 milligram after it was observed in a study that even 8 hours after taking the drug at night, some patients were not able to cope with their next-day activities like driving and other activities that require full alertness.

基本信息
英文名:
eszopiclone
CAS号.:
138729-47-2
别名:
[(7S)-6-(5-chloropyridin-2-yl)-5-oxo-7H-pyrrolo[3,4-b]pyrazin-7-yl] 4-methylpiperazine-1-carboxylate; Lunesta; Esopiclone; Estorra; UNII-UZX80K71OE; Eszopiclone;
分子式:
C17H17ClN6O3
分子量:
388.80800
PSA:
91.76000
LogP:
1.50880
物化属性
外观:
White or slightly yellowish powder
密度:
1.54 g/cm3
熔点:
202-204ºC
沸点:
580.7ºC at 760 mmHg
闪点:
305ºC
储存条件:
安全信息
海关编码:
2933599090
危险类别码:
R20/21/22; R36/37/38; R62
安全说明:
S26-S36
危险品标志:
Xn
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