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磺胺甲恶唑

英文名: sulfamethoxazole

CAS: 723-46-6      分子式: C10H11N3O3S

分子量: 253.27800

别名:


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描述

Sulfamethoxazole (SMZ or SMX), is an antibiotic. It was used for bacterial infections such as urinary tract infections, bronchitis, and prostatitis and is effective against both gram negative and positive bacteria such as Listeria monocytogenes and E. coli. Common side effects include nausea, vomiting, loss of appetite, and skin rashes. It is a sulfonamide and bacteriostatic. It resembles a component of folic acid. It prevents folic acid synthesis in the bacteria that must synthesize their own folic acid. Mammalian cells, and some bacteria, do not synthesize but require preformed folic acid (vitamin B9), they are therefore insensitive to sulfamethoxazole. It was introduced to the United States in 1961. It is now mostly used in combination with trimethoprim (abbreviated SMX-TMP). Other names include: sulfamethalazole, sulfisomezole, and sulfamethazole.

基本信息
英文名:
sulfamethoxazole
CAS号.:
723-46-6
别名:
4-amino-N-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide; Sulfamethoxazole; Benzenesulfonamide, 4-amino-N-(5-methyl-3-isoxazolyl)-;
分子式:
C10H11N3O3S
分子量:
253.27800
PSA:
106.60000
LogP:
3.10100
物化属性
外观:
Crystal or white powder
密度:
1.462 g/cm3
熔点:
166 °C
沸点:
482.1ºC at 760 mmHg
闪点:
245.4ºC
储存条件:
0-6ºC
安全信息
符号:
GHS07
信号词:
Warning
危害声明:
H315; H317; H319; H335
警示性声明:
P261; P280; P305 + P351 + P338
海关编码:
2935003000
WGK Germany:
2
危险类别码:
R22; R36/37/38
安全说明:
S26-S36-S36/37/39-S22
危险品标志:
Xn
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